WEBVTT

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CONNECTION BETWEEN THE BRAIN,
MENOPAUSE AND ALZHEIMER’S

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MENOPAUSE AND ALZHEIMER’S
DISEASE.

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DISEASE.
IT’S ALSO QUITE PERSONAL FOR

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IT’S ALSO QUITE PERSONAL FOR
HER.

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HER.
TAKE A LOOK.

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TAKE A LOOK.
>> I HAVE BEEN LOOKING INTO

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>> I HAVE BEEN LOOKING INTO
WOMEN’S BRAINS BECAUSE THEY HAVE

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WOMEN’S BRAINS BECAUSE THEY HAVE
A FAMILY HISTORY OF ALZHEIMER’S

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A FAMILY HISTORY OF ALZHEIMER’S
DISEASE.

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DISEASE.
>> NEUROSCIENTIST LISA MUSKONI’S

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>> NEUROSCIENTIST LISA MUSKONI’S
FAMILY HISTORY WITH ALZHEIMER’S

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FAMILY HISTORY WITH ALZHEIMER’S
DATES BACK TO HER MATERNAL

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DATES BACK TO HER MATERNAL
GRANDMOTHER AND TWO GREAT AUNTS,

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GRANDMOTHER AND TWO GREAT AUNTS,
BUT INTERESTINGLY THERE ARE NO

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BUT INTERESTINGLY THERE ARE NO
MALE MEMBERS OF HER FAMILY WHO

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MALE MEMBERS OF HER FAMILY WHO
HAVE EXPERIENCED IT.

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HAVE EXPERIENCED IT.
.

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.
IT’S PART OF THE REASON THAT SHE

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IT’S PART OF THE REASON THAT SHE
INVESTIGATES THE DISEASE.

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INVESTIGATES THE DISEASE.
IN FACT, ALMOST TWO OF EVERY

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IN FACT, ALMOST TWO OF EVERY
THREE ALZHEIMER’S PATIENTS ARE

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THREE ALZHEIMER’S PATIENTS ARE
WOMEN.

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WOMEN.
>> 16 YEARS AGO I KEPT ASKING IT

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>> 16 YEARS AGO I KEPT ASKING IT
SEEMS TO ME THAT MORE WOMEN ARE

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SEEMS TO ME THAT MORE WOMEN ARE
GETTING THIS DISEASE.

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GETTING THIS DISEASE.
EVERYBODY SAID TO ME IT’S ONLY

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EVERYBODY SAID TO ME IT’S ONLY
BECAUSE WOMEN LIVE LONGER.

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BECAUSE WOMEN LIVE LONGER.
NOT TRUE.

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NOT TRUE.
>> NOT TRUE.

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>> NOT TRUE.
WE TEND TO ASSOCIATE ALZHEIMER’S

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WE TEND TO ASSOCIATE ALZHEIMER’S
WITH THE ELDERLY BUT WE NOW KNOW

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WITH THE ELDERLY BUT WE NOW KNOW
IF YOU LOOK AT BRAIN SCANS, YOU

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IF YOU LOOK AT BRAIN SCANS, YOU
CAN ACTUALLY TRACE BACK THE

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CAN ACTUALLY TRACE BACK THE
ONSET OF ALZHEIMER’S DISEASE TO

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ONSET OF ALZHEIMER’S DISEASE TO
DECADES PRIOR TO THE SYMPTOMS

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DECADES PRIOR TO THE SYMPTOMS
EMERGING.

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EMERGING.
>> Reporter: SHE SAYS HER

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>> Reporter: SHE SAYS HER
RESEARCH SHOW CHANGES MAY OCCUR

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RESEARCH SHOW CHANGES MAY OCCUR
BETWEEN THE AGES OF 40 AND 65,

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BETWEEN THE AGES OF 40 AND 65,
LONG BEFORE SYMPTOMS EVEN BEGIN.

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LONG BEFORE SYMPTOMS EVEN BEGIN.
WHY IS IT THAT WOMEN TEND TO

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WHY IS IT THAT WOMEN TEND TO
DEVELOP ALZHEIMER’S EARLIER IN

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DEVELOP ALZHEIMER’S EARLIER IN
THEIR BRAINS THAN MEN?

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THEIR BRAINS THAN MEN?
>> OUR STUDIES HAVE SHOWN THAT

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>> OUR STUDIES HAVE SHOWN THAT
THERE IS A STRONG ASSOCIATION

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THERE IS A STRONG ASSOCIATION
BETWEEN THE ONSET OF ALZHEIMER’S

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BETWEEN THE ONSET OF ALZHEIMER’S
DISEASE IN THE BRAIN AND THE

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DISEASE IN THE BRAIN AND THE
ONSET OF MENOPAUSE IN WOMEN.

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ONSET OF MENOPAUSE IN WOMEN.
THIS COLOR MEANS THERE ARE

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THIS COLOR MEANS THERE ARE
PLAQUES, ALZHEIMER’S PLAQUES IN

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PLAQUES, ALZHEIMER’S PLAQUES IN
THEIR BRAIN.

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THEIR BRAIN.
>> THAT BRAIN BELONGS TO A

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>> THAT BRAIN BELONGS TO A
50-YEAR-OLD WOMAN.

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50-YEAR-OLD WOMAN.
>> IT LOOKS LIKE A BRAIN ON

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>> IT LOOKS LIKE A BRAIN ON
FIRE.

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FIRE.
>> HAVING ALZHEIMER’S PLAQUE

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>> HAVING ALZHEIMER’S PLAQUE
DOES NOT MEAN THAT SOMEONE WILL

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DOES NOT MEAN THAT SOMEONE WILL
DEVELOP DEMENTIA.

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DEVELOP DEMENTIA.
IT MEANS THAT THERE’S SOMETHING

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IT MEANS THAT THERE’S SOMETHING
IN YOUR BRAIN THAT COULD

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IN YOUR BRAIN THAT COULD
POTENTIALLY CAUSE IT.

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POTENTIALLY CAUSE IT.
WE KNOW THAT ESTROGEN IS

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WE KNOW THAT ESTROGEN IS
PROTECTIVE AGAINST THE PLAQUES

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PROTECTIVE AGAINST THE PLAQUES
AND WHEN THE ESTROGENS GO DOWN,

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AND WHEN THE ESTROGENS GO DOWN,
THE PLAQUES START POPPING UP.

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THE PLAQUES START POPPING UP.
>> AND YOU’RE SAYING ACTUALLY

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>> AND YOU’RE SAYING ACTUALLY
MENOPAUSE MEANS YOUR BRAIN IS

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MENOPAUSE MEANS YOUR BRAIN IS
CHANGING.

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CHANGING.
>> YES, YOUR BRAIN IS ACTUALLY

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>> YES, YOUR BRAIN IS ACTUALLY
CHANGING.

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CHANGING.
WE TEND TO THINK ABOUT OUR

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WE TEND TO THINK ABOUT OUR
BRAINS AS SOMETHING THAT IS

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BRAINS AS SOMETHING THAT IS
ISOLATED FROM THE REST OF US,

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ISOLATED FROM THE REST OF US,
BUT IN REALITY, SOMETHING IS

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BUT IN REALITY, SOMETHING IS
HAPPENING IN YOUR ORGANS, YOUR

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HAPPENING IN YOUR ORGANS, YOUR
BRAIN WILL ALSO BE AFFECTED OR

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BRAIN WILL ALSO BE AFFECTED OR
INFLUENCED BY IT.

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INFLUENCED BY IT.
>> FOR THIS REASON, MUSKONI

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>> FOR THIS REASON, MUSKONI
STUDIES MENOPAUSAL WOMEN

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STUDIES MENOPAUSAL WOMEN
EXAMINING BLOOD WORK, COGNITIVE

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EXAMINING BLOOD WORK, COGNITIVE
TESTING, GENETICS, AND BRAIN

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TESTING, GENETICS, AND BRAIN
SCANS.

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SCANS.
>> THIS IS DEB’S BRAIN.

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>> THIS IS DEB’S BRAIN.
>> 53-YEAR-OLD DEBRA COPAKIN

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>> 53-YEAR-OLD DEBRA COPAKIN
DESIGNED UP FOR THE STUDY AFTER

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DESIGNED UP FOR THE STUDY AFTER
INTERVIEWING MASCONY FOR AN

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INTERVIEWING MASCONY FOR AN
ARTICLE AND FOUND SIMILARITIES

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ARTICLE AND FOUND SIMILARITIES
BETWEEN WHAT SHE WAS REPORTING

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BETWEEN WHAT SHE WAS REPORTING
ON AND WHAT SHE WAS ACTUALLY

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ON AND WHAT SHE WAS ACTUALLY
EXPERIENCING HERSELF.

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EXPERIENCING HERSELF.
>> I’M HAVING ALL SORTS OF WORD

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>> I’M HAVING ALL SORTS OF WORD
RECALL ISSUES, FOR EXAMPLE, I

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RECALL ISSUES, FOR EXAMPLE, I
WAS HOLDING AN ARTICHOKE IN MY

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WAS HOLDING AN ARTICHOKE IN MY
HAND, AND I COULDN’T COME UP

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HAND, AND I COULDN’T COME UP
WITH THE NAME.

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WITH THE NAME.
>> DID THAT JUST FREAK YOU OUT?

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>> DID THAT JUST FREAK YOU OUT?
>> IT FREAKS ME OUT ALL THE

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>> IT FREAKS ME OUT ALL THE
TIME, AND SO ONE OF THE REASONS

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TIME, AND SO ONE OF THE REASONS
I WAS TALKING TO THE DOCTOR IS

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I WAS TALKING TO THE DOCTOR IS
TO FIND OUT WHAT IS THE

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TO FIND OUT WHAT IS THE
MENOPAUSE/ALZHEIMER’S CONNECTION

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MENOPAUSE/ALZHEIMER’S CONNECTION
AND SHOULD I BE CONCERNED.

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AND SHOULD I BE CONCERNED.
>> STACY PURVALL, A 61-YEAR-OLD

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>> STACY PURVALL, A 61-YEAR-OLD
ENTREPRENEUR REACHED OUT AFTER

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ENTREPRENEUR REACHED OUT AFTER
READING THE ARTICLE,

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READING THE ARTICLE,
AFRICAN-AMERICAN WOMEN HAVE

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AFRICAN-AMERICAN WOMEN HAVE
TWICE THE RISK OF ALZHEIMER’S

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TWICE THE RISK OF ALZHEIMER’S
AND DEMENTIA AS WHITE WOMEN.

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AND DEMENTIA AS WHITE WOMEN.
>> YOU HEAR A CALL OUT FOR WOMEN

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>> YOU HEAR A CALL OUT FOR WOMEN
TO PARTICIPATE AND PARTICULARLY

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TO PARTICIPATE AND PARTICULARLY
WOMEN OF COLOR, YEP, I’M IN.

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WOMEN OF COLOR, YEP, I’M IN.
>> BEING A FAMILY CARE GIVER FOR

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>> BEING A FAMILY CARE GIVER FOR
FAMILY MEMBERS WITH DEMENTIA,

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FAMILY MEMBERS WITH DEMENTIA,
IT’S STILL VERY A MUCH A

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IT’S STILL VERY A MUCH A
LONG-TERM FEAR OF MINE THAT THAT

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LONG-TERM FEAR OF MINE THAT THAT
COULD BE MY FUTURE.

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COULD BE MY FUTURE.
PARTICIPATING HELPS ME TO DO

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PARTICIPATING HELPS ME TO DO
SOMETHING CONSTRUCTIVE ABOUT

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SOMETHING CONSTRUCTIVE ABOUT
THAT.

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THAT.
>> HAVE YOU LOOKED AT YOUR BRAIN

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>> HAVE YOU LOOKED AT YOUR BRAIN
SCANS?

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SCANS?
>> I HAVE NOT.

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>> I HAVE NOT.
>> WHAT DID YOU THINK, WERE YOU

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>> WHAT DID YOU THINK, WERE YOU
SCARED?

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SCARED?
>> YES AND NO.

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>> YES AND NO.
YES BECAUSE ONE IS ALWAYS SCARED

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YES BECAUSE ONE IS ALWAYS SCARED
AND I DON’T WANT TO FIND

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AND I DON’T WANT TO FIND
SOMETHING IN THERE, BUT NO,

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SOMETHING IN THERE, BUT NO,
BECAUSE WHAT CAN I DO ABOUT IT,

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BECAUSE WHAT CAN I DO ABOUT IT,
I’M GOING TO GET THIS

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I’M GOING TO GET THIS
INFORMATION.

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INFORMATION.
IT’S GOING TO GIVE ME MORE

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IT’S GOING TO GIVE ME MORE
KNOWLEDGE ABOUT HOW TO TREAT MY

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KNOWLEDGE ABOUT HOW TO TREAT MY
BODY, HOW TO TREAT MY BRAIN.

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BODY, HOW TO TREAT MY BRAIN.
>> ARE YOU SCARED TO SEE YOUR

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>> ARE YOU SCARED TO SEE YOUR
BRAIN SCAN?

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BRAIN SCAN?
>> NO.

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>> NO.
AND NOW I’M SUPER LIKE EVEN MORE

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AND NOW I’M SUPER LIKE EVEN MORE
EXCITED TO WANT TO SEE IT.

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EXCITED TO WANT TO SEE IT.
>> ALZHEIMER’S IS NOT

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>> ALZHEIMER’S IS NOT
NECESSARILY A HEALTH QUEST

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NECESSARILY A HEALTH QUEST
DISEASE THAT IS SO MUCH IN OUR